Contingency Management for PrEP Adherence and/or Methamphetamine Use

Completed · Not applicable

Conditions studied: Methamphetamine-dependence, HIV-1-infection

In brief

Use of crystal methamphetamine (MA) leads to changes in sexual risk behavior, adherence to HIV prevention tools, immune response to infection, and tissue inflammation that collectively increase risk for HIV transmission among MA-using men who have sex with men (MSM), their sexual partners, and their networks. Contingency Management (CM) offers a behavioral modification tool helpful for reducing frequency of MA use, but the effects of CM on the behavioral and biological factors that promote HIV transmission in MSM networks have only been partially evaluated. The intersection of substance use, sexual risk behavior, and HIV transmission in MSM networks presents a critical problem for contemporary HIV prevention as HIV-uninfected MSM who use MA have a 16%-33% greater risk for HIV infection, while only approximately 50% of HIV-infected MA-using MSM achieve and maintain an undetectable viral load. The investigators propose to compare two different CM models to integrate substance use treatment with HIV prevention among MA-using MSM: 1) Traditional CM targeted to MA abstinence and 2) Allternative CM based on ARV adherence.

Key facts

Study ID

NCT04563962

Run by

University of California, Los Angeles

People needed

20

Starts

2021-03-15

Expected to finish

2021-08-31

Last updated by the study team

2021-09-29

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Identify as male or transgender female;
• Report sexual intercourse with a male or transgender female partner in the prior 6 months;
• Report current MA use (at least once per week) with MA present in urine at screening; and
• Taking Truvada or Descovy for PrEP (if HIV-uninfected) or a Tenofovir-based ART regimen (if HIV-infected).

You may not qualify if…

• Exclusion Criteria (for all study components):
• Inability to understand the study procedures or to provide informed consent
• Not taking a tenofovir-based regimen for HIV prevention or treatment
• Actively seeking treatment for Methamphetamine Use Disorder (MUD)

Where it is running

• UCLA Vine Street Clinic — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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