ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

Recruiting now

Conditions studied: Transthyretin-Mediated Amyloidosis, ATTR Amyloidosis

In brief

The purpose of this study is to: * Describe epidemiological and clinical characteristics, natural history and real-world clinical management of ATTR amyloidosis patients * Characterize the safety and effectiveness of patisiran and vutrisiran as part of routine clinical practice in the real-world clinical setting * Describe disease emergence/progression in pre-symptomatic carriers of a known disease-causing transthyretin (TTR) variant

Key facts

Study ID

NCT04561518

Run by

Alnylam Pharmaceuticals

People needed

1500

Starts

2020-11-23

Expected to finish

2033-12-31

Last updated by the study team

2026-05-29

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of ATTR amyloidosis or documented known disease-causing TTR variant for the cohort of pre-symptomatic carriers
• Germany Only: Patients must be treated per the summary of product characteristics (SmPC) for any approved treatment for ATTR amyloidosis

You may not qualify if…

• Current enrollment in a clinical trial for any investigational agent

Where it is running

• Clinical Trial Site — Taipei, Taiwan (enrolling)
• Clinical Trial Site — Los Angeles, California, United States (enrolling)
• Clinical Trial Site — Jacksonville, Florida, United States (enrolling)
• Clinical Trial Site — Iowa City, Iowa, United States (enrolling)
• Clinical Trial Site — Kansas City, Kansas, United States (enrolling)
• Clinical Trial Site — Baltimore, Maryland, United States (enrolling)
• Clinical Trial Site — New Taipei City, Taiwan (enrolling)
• Clinical Trial Site — La Jolla, California, United States (enrolling)
• Clinical Trial Site — New York, New York, United States (enrolling)
• Clinical Trial Site — Durham, North Carolina, United States (enrolling)
• Clinical Trial Site — Columbus, Ohio, United States (enrolling)
• Clinical Trial Site — Philadelphia, Pennsylvania, United States (enrolling)
• Clinical Trial Site — Austin, Texas, United States (enrolling)
• Clinical Trial Site — Houston, Texas, United States (enrolling)
• Clinical Trial Site — Salvador, Brazil (enrolling)
• Clinical Trial Site — São Paulo, Brazil (enrolling)
• Clinical Trial Site — Sofia, Bulgaria (enrolling)
• Clinical Trial Site — Aarhus, Denmark (enrolling)
• Clinical Trial Site — Bordeaux, France (enrolling)
• Clinical Trial Site — Bron, France (enrolling)
• Clinical Trial Site — Créteil, France (enrolling)
• Clinical Trial Site — Le Kremlin-Bicêtre, France (enrolling)
• Clinical Trial Site — Marseille, France (enrolling)
• Clinical Trial Site — Berlin, Germany (enrolling)
• Clinical Trial Site — Giessen, Germany (enrolling)

Full record on ClinicalTrials.gov

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