Ketamine-enhanced Prolonged Exposure Therapy in PTSD

Completed · Phase 2 · Has a placebo group

Conditions studied: PTSD

In brief

The purpose of this study is to test the safety and efficacy of repeated doses of ketamine as compared to placebo to reduce symptoms of Posttraumatic Stress Disorder (PTSD) among Veteran receiving Prolonged Exposure Therapy.

Key facts

Study ID

NCT04560660

Run by

VA Office of Research and Development

People needed

75

Starts

2021-03-09

Expected to finish

2025-10-07

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• male or female Veterans between the ages of 18 and 75 years
• diagnosis of PTSD
• ability to provide written informed consent

You may not qualify if…

• females who are currently pregnant or breastfeeding
• current high risk for suicide
• history of moderate/severe head injury
• history of psychosis
• current episode of mania/hypomania
• severe substance and/or alcohol use disorder in the last 6 months

Where it is running

• Minneapolis VA Health Care System, Minneapolis, MN — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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