Enhancement of the Haemostatic Effect of Platelets in the Presence of High Normal Concentrations of Von Willebrand Factor

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Bleeding

In brief

Assessment of high-normal dosage of Wilate ® compared to placebo administered in combination with platelets to assess reduction of amount of blood loss, need of transfusion products and outcome (length of stay, mortality) in patients with bleeding in comparison.

Key facts

Study ID

NCT04555785

Run by

University Hospital, Basel, Switzerland

People needed

120

Starts

2022-04-01

Expected to finish

2028-11-01

Last updated by the study team

2026-06-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Admission to intensive care unit
• Patients needing platelet transfusion during or after surgery with or without prior treatment with single or dual antiplatelet agents (ASS, Prasugrel, Clopidogrel, Ticagrelor)
• Consent by the patient or a family member in addition to the consent of an independent ICU physician

You may not qualify if…

• Patients receiving Factor VIII concentrate before inclusion of the study (Haemate ®)
• Women who are pregnant or breastfeeding
• Participation in another study with an investigational drug within the 30 days preceding and during the present study
• Overt Disseminated Intravascular Coagulation (DIC)
• Heparin-induced Thrombocytopenia (HIT)
• Thrombotic Thrombocytopenic Purpura (TTP) or Haemolytic uremic Syndrome (HUS)
• Idiopathic thrombocytopenic purpura (ITP)
• Sepsis
• Patients with known inherited thrombocytopathies
• Patients with known von Willebrand disease or Haemophilia A
• Patients with known hemato-oncological diseases
• Previous enrolment into the current study
• Contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to class of drugs or the investigational product.

Where it is running

• University Hospital Basel — Basel, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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