The Maintenance Effect of Enstilar Foam in Combination With Otezla

Status unconfirmed · Phase 4

Conditions studied: Psoriasis

In brief

This is a single-center, open-label study. Approximately 30 qualified subjects will be enrolled in a study lasting 20 weeks which investigates the effect of Enstilar used in combination with Otezla to treat psoriasis.

Key facts

Study ID

NCT04555707

Run by

Derm Research, PLLC

People needed

30

Starts

2020-06-24

Expected to finish

2021-09-30

Last updated by the study team

2020-10-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Outpatient, male or female subjects of any race, 18 years of age or higher. Female subjects of childbearing potential must have a (-)UPT result at within 7 days of the first dose of study drug and practice a reliable method of contraception throughout the study;
• A female is considered of childbearing potential unless she is:
• postmenopausal > 5Y, without a uterus and/or both ovaries; or has been surgically sterile for > 6M.
• Reliable methods of contraception are:
• hormonal methods or IUD in use > 90d prior to study drug administration, barrier methods plus spermicide in use > 14d prior, or vasectomized partner.
• [Exception: Female subjects of CBP who are not sexually active are not required to practice a reliable method of contraception and may be enrolled at the Investigator's discretion provided they are counseled to remain sexually inactive for the duration of the study and understand the risks involved in getting pregnant during the study.]
• Subjects with moderate plaque type psoriasis who have been started on commercial Otezla within the last 10 days
• Physician Global Assessment (PGA) score of 3
• Able to understand study requirements and sign Informed Consent/HIPAA forms

You may not qualify if…

• Female subjects who are pregnant, breast-feeding, or who are of childbearing potential and not practicing a reliable method of birth control, or male subjects planning a pregnancy with their spouse or partner while in the study
• History of hypercalcemia or Vitamin D toxicity or history of significant renal or hepatic disease
• Patients with guttate, erythrodermic, or pustular psoriasis
• Serious skin condition (other than psoriasis) or uncontrolled medical condition (in the opinion of the investigator.)
• Skin conditions (e.g. eczema) that may interfere with evaluations of psoriasis
• Known hypersensitivity to Enstilar Foam or any of its components
• Current drug or alcohol abuse (Investigator opinion.)
• Subject unable to commit to all the assessments required by the protocol
• Current enrollment in another clinical study and treatment with another experimental drug or approved therapy for experimental use within 30 days prior to the Screening Visit.

Where it is running

• Skin Sciences, PLLC — Louisville, Kentucky, United States (enrolling)

Full record on ClinicalTrials.gov

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