Temporal, Environmental, and Genetic Factors Regulating Exercise and Migraine

Completed · Not applicable

Conditions studied: Migraine Disorders

In brief

Chronic pain, of which migraine is among the most common, affects 100 million US adults and costs between $560 to $635 billion dollars annually. There is a need for effective, low-cost non-pharmacological strategies to reduce migraine load in migraineurs (based on International Headache Society classification International Classification of Headache Disorders \[ICHD\]-3; experience headache \[migraine-like or tension-type-like\] on 15+ days/month for 3+ months, and have migraine headaches \[either with aura or without aura\] on 8+ days/month). This represents an area of interest, as common migraine medications induce central nervous system side-effects including aphasia, ataxia, somnolescence, and vertigo; and 79% of suffers have an interest in trying novel treatment strategies with lower adverse effects than medications. Exercise has been shown to be a non-pharmacological intervention to reduce migraine burden. However, how environmental (i.e. - time-of-day, exposure to nature) and genetic factors (i.e. - polymorphisms in circadian and migraine associated genes) impact the laudatory effects of exercise remains unknown. There are independently established heritable components to migraine frequency (65%), circadian rhythm (70%), and aerobic power during exercise (66%). Thus, the central hypothesis is that an optimal environment can improve the exercise-induced reduction in migraine load, which is influenced by genetic heritability of migraine related gene polymorphisms.

Key facts

Study ID

NCT04553445

Run by

University of Nevada, Las Vegas

People needed

18

Starts

2020-11-23

Expected to finish

2022-05-31

Last updated by the study team

2022-11-28

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants must be classified as a chronic migraineur: based on the International Headache Society classification ICHD-3; experience headache (migraine-like or tension-type-like) on 15+ days/month for 3+ months, and have migraine headaches (either with aura or without aura) on 8+ days/month.
• Participants also must also be classified into a discrepant chronotype: screened using the Morningness/Eveningness Questionnaire, into Definite Morning and Morning types; and Definite Evening and Evening types.

You may not qualify if…

• Not classified as a chronic migraineur.
• Not classified into a discrepant chronotype.
• Not classified as low health risk.

Where it is running

• University of Nevada, Las Vegas — Las Vegas, Nevada, United States

Full record on ClinicalTrials.gov

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