Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Mycobacterium Avium Complex, Non-tuberculous Mycobacterium Pulmonary Disease

In brief

To evaluate the pharmacokinetics (PK) of SPR719, the active moiety, generated from the orally (po) administered SPR720 prodrug in a patient population with nontuberculous mycobacteria pulmonary disease (NTM-PD)

Key facts

Study ID

NCT04553406

Run by

Spero Therapeutics

People needed

2

Starts

2020-12-03

Expected to finish

2021-01-28

Last updated by the study team

2022-02-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Has a diagnosis of NTM-PD due to MAC
• Had at least 1 prior positive culture (sputum or bronchoalveolar lavage) positive for MAC in the previous 6 months
• Has an induced sputum culture at screening positive for MAC by at least one of the following methods performed by the microbiology laboratory: quantitative culture on solid agar or growth on liquid media (MGIT)
• Is either treatment naïve and has not received any prior treatment for MAC, OR if previously treated for MAC, has culture evidence of persistent, recurrent, or relapsed disease and has been off therapy for at least 6 months
• In the opinion of the Investigator, is ready to initiate treatment (treatment naïve) or reinitiate treatment (previously treated) within the next 3 months, and for whom a delay, in order to participate in a placebo-controlled clinical trial, is considered reasonable and clinically acceptable
• Had clinical signs and symptoms within the 6 weeks before the date of consent that are consistent with NTM-PD with at least two of the following:
• chronic cough
• fatigue
• frequent throat clearing
• shortness of breath (dyspnea)
• coughing up of blood (hemoptysis)
• excessive mucus (sputum) production
• fever
• night sweats
• loss of appetite
• unintended weight loss
• wheezing
• chest pain
• Has a measured forced expiratory volume in 1 second (% predicted FEV1) ≥30% on pulmonary function test within 3 months prior to consent
• Has a chest radiograph (CXR) or computed tomography (CT) scan within 6 months prior to consent with findings consistent with NTM-PD. If no CXR or CT scan is available, a CXR or CT scan should be performed at screening to confirm eligibility.
• Other inclusion criteria per protocol

You may not qualify if…

• Has disseminated or extrapulmonary NTM
• Has end-stage NTM-PD or treatment-refractory NTM-PD and is unlikely to respond to protocol-specified SOC treatment
• Had isolation on sputum cultures of any species of Mycobacterium other than a species included in MAC within the past 6 months
• Had prior isolation of MAC with macrolide resistance
• Has received any systemic (oral or IV) or inhaled antibiotic with activity against MAC between consent and randomization
• Has a potentially confounding underlying pulmonary disease, including but not limited to cystic fibrosis, active pulmonary malignancy (primary or metastatic), NTM-hypersensitivity disease pneumoconiosis, or another advanced lung disease with a % predicted FEV1<30%
• Other exclusion criteria per protocol

Where it is running

• Medical Facility — Altamonte Springs, Florida, United States
• Medical Facility — Atlantis, Florida, United States
• Medical Facility — Clearwater, Florida, United States
• Medical Facility — Kissimmee, Florida, United States
• Medical Facility — West Palm Beach, Florida, United States
• Medical Facility — Charlotte, North Carolina, United States
• Medical Facility — Mooresville, North Carolina, United States
• Medical Facility — Winston-Salem, North Carolina, United States
• Medical Facility — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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