Stress and Congestive Heart Failure

Recruiting now · Not applicable

Conditions studied: Congestive Heart Failure

In brief

The purpose of this study is to investigate whether acute stress can precipitate congestive heart failure (CHF) exacerbation in patients with CHF.

Key facts

Study ID

NCT04551560

Run by

Yale University

People needed

112

Starts

2020-12-02

Expected to finish

2026-04-30

Last updated by the study team

2026-01-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Heart failure patients over 18 who have or will be receiving a Cardiomems implanted PAP monitor.

You may not qualify if…

• Patients who are unable to perform EMA or laboratory assessments due to cognitive, visual, language, or other disabilities will be excluded.
• Patients with Class IV heart failure will also be excluded, as they are already maximally decompensated, and a ceiling/floor effect would preclude effects of stress.
• Patients with conditions other than heart failure that affect PA pressures (e.g. dialysis).
• Patients with physical conditions that interfere with study participation.
• Patients non-compliant with their PAP monitoring.
• Patients with chronic opioid use will be excluded.

Where it is running

• St. Francis Hospital — Hartford, Connecticut, United States (enrolling)
• Yale University — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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