Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors

Stopped early

Conditions studied: Gender Incongruence, Transgenderism

In brief

The purpose of this research is to find out if hormone therapy in transgender subjects' changes hormone receptors in blood, muscle and fat; fat production; muscle production; and inflammation processes.

Key facts

Study ID

NCT04551144

Run by

St. Louis University

People needed

4

Starts

2020-10-06

Expected to finish

2023-01-18

Last updated by the study team

2024-01-08

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with gender incongruence by a mental health professional and willing to start gender affirming therapy

You may not qualify if…

• Used hormone therapy in last 6 months,
• Pregnancy,
• Planning to have biological children in the next one year,
• HIV Additional exclusion criteria for transmen: 1) hematocrit >50% for transmen, 2) transmen with allergy to cottonseed oil (component of intramuscular testosterone injection), 3) uncompensated heart failure, 4) renal failure Additional exclusion criteria for transwomen: 1) allergy to castor oil (component of intramuscular estradiol injection), 2) Known or suspected estrogen-dependent neoplasia, 3) Active deep vein thrombosis, pulmonary embolism or a history of these conditions, 4) Active or recent (e.g., within the past year) arterial thromboembolic disease (e.g., stroke, myocardial infarction), 5) Liver enzymes (AST or ALT) >3 times the upper limit of normal, 6) Known or suspected pregnancy

Where it is running

• Saint Louis Univeristy — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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