Safety of Lung Cryobiopsy in People With Cancer

Completed · Phase 2

Conditions studied: Lung Cancer

In brief

The purpose of this study is to find out whether a biopsy technique called transbronchial cryobiopsy (TBCB) is a safe alternative to the standard biopsy procedure (transbronchial forceps biopsy; TBFB). The study researchers think that TBCB may provide better biopsy samples to help diagnose lung disease.

Key facts

Study ID

NCT04548830

Run by

Memorial Sloan Kettering Cancer Center

People needed

115

Starts

2020-09-08

Expected to finish

2026-06-30

Last updated by the study team

2026-07-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or greater
• Patients with known or suspected diagnosis of cancer and indeterminant pulmonary nodules or diffuse parenchymal lung disease with non-diagnostic clinical profiles for whom a lung biopsy is deemed useful for diagnosis.

You may not qualify if…

• Patients with pulse oximetry less than 92% on oxygen delivery up to 2 L nasal cannula.
• Uncorrectable coagulopathy defined as:
• Platelet count <50,000 x 10\^9/L or
• prothrombin time international normalized ratio >1.5
• Known pulmonary hypertension or echocardiographic pulmonary artery systolic pressure >50mmHg
• A secure diagnosis based on clinical and high-resolution CT scan data.
• Antiplatelet therapy that cannot be held for more than 5 days.
• Any patient deemed unfit to undergo bronchoscopy by the proceduralist
• Female patients with a positive pregnancy test within 30 days of the planned study procedure

Where it is running

• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States

Full record on ClinicalTrials.gov

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