Jump: MR Simulation For Radiation Therapy Master Protocol

Recruiting now · Not applicable

Conditions studied: Prostate Cancer, Recurrent Adenocarcinoma, Liver Cancer, Head and Neck Cancer

In brief

This is a master protocol for a prospective Phase I-II study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (MRI) simulation into the planning of radiation treatments.

Key facts

Study ID

NCT04545957

Run by

Brigham and Women's Hospital

People needed

86

Starts

2020-10-14

Expected to finish

2030-10-22

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants must have a confirmed malignancy requiring radiation therapy.
• Age: 18 years or older
• ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)
• Ability to understand and the willingness to sign a written informed consent document.
• Disease-specific eligibility criteria will be specified in the appropriate subprotocol.

You may not qualify if…

• For MRI involving contrast, history of allergic reactions attributed to gadolinium based IV contrast. Note: If patient will not receive contrast, this is not applicable
• Participants who cannot undergo an MRI
• Disease-specific exclusion criteria will be specified in the appropriate subprotocol

Where it is running

• Brigham and Women Hospital — Boston, Massachusetts, United States (enrolling)
• Dana Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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