A Nurse-led Intervention to Extend the Veteran HIV Treatment Cascade for Cardiovascular Disease Prevention
Completed · Not applicable
Conditions studied: Cardiovascular Disease, Hypertension, Care Coordination, HIV Treatment Cascade
In brief
The VA is the largest single provider of HIV care in the US and Veterans with HIV use significantly more healthcare services and have a 1.5-2x higher risk of atherosclerotic cardiovascular disease (ASCVD) compared to uninfected Veterans. The goal is to improve BP treatment for Veterans with HIV to reduce ASCVD risk. Within a randomized controlled trial (RCT), the investigators hypothesize that the VA adapted nurse-led intervention will result in a clinically significant 6 millimeters of mercury (mmHg) reduction in systolic blood pressure (SBP) over 12 months compared to those receiving enhanced education only. The study is innovative because of the use of stakeholder-engaged design process, multi-component nurse-led intervention, and VA Video Connect (VVC) to monitor CVD risk factors. The project meets VA strategic priorities including: 1) greater choice for Veterans; 2) improve timeliness of services; 3) focus more resources more efficiently (strengthen foundational services in VA). If shown to be effective, this intervention will have substantial impact among high-risk Veterans, potentially reducing ASCVD events by more than a quarter.
Key facts
- Study ID
- NCT04545489
- Run by
- VA Office of Research and Development
- People needed
- 305
- Starts
- 2020-12-01
- Expected to finish
- 2025-03-31
- Last updated by the study team
- 2025-10-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age => 18 years
- Confirmed HIV+ diagnosis
- Undetectable HIV viral load: defined as the most recent HIV viral load < 200 copies/mL, checked within the past 18 months (assessed via chart abstraction)
- Hypertension: defined as the average of 4 most recent outpatient BP measurements in the last 18 months to show systolic BP 130 and/or diastolic 90 mmHg (assessed via chart abstraction)
- Veteran at one of the sites participating in the study
- Regular access to a computer, tablet or smart phone device with internet.
You may not qualify if…
- Severely hearing or speech impaired, or other disability that would limit participation
- In a nursing home at baseline and/or any long-term care facility. Individuals will be censored at the point of entering nursing home care
- In-patient psychiatric care
- Diagnosis of dementia or active psychosis
- Terminal illness with life expectancy < 4 months (ex. Metastatic cancer, Hospice care)
- Recent (<90day) hospitalization for coronary artery bypass surgery (CABG), myocardial infarction (MI), stroke)
- Pregnant, breast-feeding, or planning a pregnancy during the study period
- Planning to move out of the area in the next 12 months.
- No reliable access to telephone services
Where it is running
- Atlanta VA Medical and Rehab Center, Decatur, GA — Decatur, Georgia, United States
- Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD — Baltimore, Maryland, United States
- Durham VA Medical Center, Durham, NC — Durham, North Carolina, United States
- Louis Stokes VA Medical Center, Cleveland, OH — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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