The clonoSEQ® Watch Registry

Stopped early

Conditions studied: Acute Lymphoblastic Leukemia, Adult B-Cell, Chronic Lymphocytic Leukemia, Multiple Myeloma, Non-hodgkin Lymphoma

In brief

This is a prospective, multicenter, observational study of adult patients with a diagnosis of acute lymphoblastic leukemia (ALL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL), or non-Hodgkin lymphoma (NHL). This study will enroll up to 528 patients in up to 50 sites in the United States and collect data with regard to use of the clonoSEQ MRD assay in the management of lymphoid malignancies.

Key facts

Study ID

NCT04545333

Run by

Adaptive Biotechnologies

People needed

465

Starts

2020-10-13

Expected to finish

2023-10-01

Last updated by the study team

2024-08-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must be able to provide written informed consent
• A decision has been made by the treating provider to use the clonoSEQ Assay as part of routine clinical care
• Age ≥ 18 years;
• Documented hematologic malignancy (any of the below):
• MM
• ALL (B and T-cell subtypes)
• B-cell NHL (all sub types)
• CLL
• Other lymphoid malignancies (upon review and approval by study chair)

You may not qualify if…

• Patients must not meet any of the following criteria in order to be enrolled into the study:
• Concurrent enrollment in a clinical trial where treatment decisions and patterns are dictated per protocol
• A decision has been made by the treating provider to not use the clonoSEQ Assay as part of routine clinical care

Where it is running

• Stanford Hospital — Stanford, California, United States
• Georgetown University — Washington D.C., District of Columbia, United States
• Holy Cross Hospital — Fort Lauderdale, Florida, United States
• Edward H. Kaplan MD & Associates — Skokie, Illinois, United States
• Hematology Oncology Clinic — Baton Rouge, Louisiana, United States
• American Oncology Partners of Maryland — Bethesda, Maryland, United States
• Washington University — St Louis, Missouri, United States
• Novant Health — Charlotte, North Carolina, United States
• Oregon Health & Science University, Knight Cancer Institute — Portland, Oregon, United States
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Bon Secours St Francis — Greenville, South Carolina, United States
• University of Washington, Seattle Cancer Care Alliance — Seattle, Washington, United States
• Swedish Cancer Institute — Seattle, Washington, United States
• Northwest Medical Specialties — Tacoma, Washington, United States

Full record on ClinicalTrials.gov

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