The Role of the Nasal Allergen Provocation Test in Starting and Monitoring Allergen Immunotherapy
Recruiting now
Conditions studied: Perennial Allergic Rhinitis, Seasonal Allergic Rhinitis, Local Allergic Rhinitis
In brief
This prospective multicentric academic NAPT study aims to compile a database of all patients who initiate immunotherapy. The NAPT will take place before, during and after AIT to evaluate the cost and effectiveness of the treatment. The study consists of 4 visits and 2 telephone contacts that are repeated annually for 3 years. This study will be conducted in 2 hospitals: UZ Leuven and AZ ST. Jan Brugge on the consultation Ear, Nose and Throat Diseases (ENT) and the department of Internal Medicine / Allergology
Key facts
- Study ID
- NCT04544774
- Run by
- Universitaire Ziekenhuizen KU Leuven
- People needed
- 200
- Starts
- 2020-07-16
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-05-01
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age >18 and ≤60 years
- Persistent or intermittent allergic rhinitis complaints, confirmed by SPT and/of immunocap for the specific IgEs.
- OR suspected local allergic rhinitis
- Patients who start with AIT treatment
- The patient must be motivated and willing to come to all visits
- The patient must be able to understand and sign the informed consent
You may not qualify if…
- Uncontrolled asthma
- Conditions affecting the functioning of the immune system (eg: immune deficiencies, malignancies, autoimmune diseases)
- Use of β-blockers, immunosuppressants or ACE inhibitors
- Hypersensitivity to aluminum hydroxide and/or hypersensitivity to any of the excipients in AIT
- Anaphylaxis after allergen challenge in the past
- Acute rhinosinusitis in the last 12 weeks
- Recent surgery on the nose and/or paranasal sinuses in the last 12 weeks
- Pregnancy
Where it is running
- UZ Leuven — Leuven, Vlaam Brabant, Belgium (enrolling)
- AZ Sint-Jan — Bruges, Belgium
Full record on ClinicalTrials.gov
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