Neuromodulation in Lower Limb Amputees

Stopped early · Not applicable

Conditions studied: Amputation, Phantom Limb Pain, Hoffman's Reflex

In brief

The goal of this study is to investigate the role of transcutaneous spinal cord stimulation on spinal cord excitability in lower limb amputees. In this study, the investigators will quantify the spinal cord excitability determined by 1) reflexes and electromyography, and 2) phantom limb pain using self-reported pain assessments. The investigators will assess these measures of spinal excitability in lower limb amputees before and after transcutaneous spinal cord stimulation.

Key facts

Study ID

NCT04543786

Run by

University of Pittsburgh

People needed

3

Starts

2022-03-07

Expected to finish

2022-06-29

Last updated by the study team

2023-07-24

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants must be between the ages of 21 and 70 years old.
• Participants must have a trans-tibial amputation and phantom limb pain in at least one leg

You may not qualify if…

• Participants must not have any serious disease, disorder, or infection (ex. blood or bone disorder or infection) that could affect their ability to participate in this study.
• Female participants of child-bearing potential must not be pregnant or breast feeding, or plan to become pregnant during the course of the study.
• Participants must not have any implanted stimulators or pulse generators
• Participants must not have any implanted metallic devices in their torso and/or legs
• Participants must not have heart disease, including known arrhythmia

Where it is running

• Carnegie Mellon University — Pittsburgh, Pennsylvania, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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