Individualized Targeting and Neuromodulation of Late-Life Depression

Running, not enrolling · Not applicable

Conditions studied: Major Depressive Disorder

In brief

An open-label, single-arm, clinical research study about how to make transcranial magnetic stimulation (TMS), an FDA-approved treatment, more effective for patients with late-life depression using fMRI.

Key facts

Study ID

NCT04543773

Run by

University of New Mexico

People needed

24

Starts

2024-10-01

Expected to finish

2026-09-01

Last updated by the study team

2026-08-04

Who can join

Age: 60 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant must be at least 60 years of age (all genders, races, and ethnicities), and less than or equal to 79 years of age.
• Participant must have a diagnosis of major depressive disorder without psychosis for the past 6 months, as diagnosed by a board-certified psychiatrist
• Must show evidence of being in a current major depressive episode, as indicated by score on QIDS-C of 10 or higher.
• Participant must not have any conditions listed in the exclusion criteria
• Participant must be fluent in English

You may not qualify if…

• Current diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or any other psychotic disorder
• Substance use disorder, abuse or dependence, with active use within the last 3 months
• Legal or mental incompetency, or inability to consent to study
• Unstable medical illness, or hospitalization within 3 weeks of study entry
• Current diagnosis of a neurological disorder or neurocognitive disorder
• Prior neurosurgical procedure
• History of seizure
• History of ECT treatment within the past three months
• History of any previous TMS treatment
• Any contraindication to obtaining magnetic resonance imaging safely
• Pregnant women
• Inability to complete the protocol, namely, inability to independently attend all study visits and TMS sessions on time.

Where it is running

• University of New Mexico HSC — Albuquerque, New Mexico, United States

Full record on ClinicalTrials.gov

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