American Lung Association (ALA) Lung Health Cohort

Recruiting now

Conditions studied: Lung Diseases

In brief

The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000 young adults between the ages of 25-35 who do not have severe lung disease. The overarching objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.

Key facts

Study ID

NCT04543461

Run by

Johns Hopkins University

People needed

4000

Starts

2021-10-29

Expected to finish

2026-09-01

Last updated by the study team

2026-02-04

Who can join

Age: 25 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 1- Age 25-35 years at the time of the baseline examination 2- Able to read and understand English or Spanish 3 -Has a social security number 4- Resident (citizen or non-citizen) of the United States (US) for at least 12 months prior to examination. Note: Individuals who are residents of the US who have temporarily spent time living outside of the US during the last 12 months (e.g., student exchange program, military posting) are eligible for participation.
• 5- Willing to provide contact information for at least 2 proxies who are likely to know the whereabouts and vital status of the participant

You may not qualify if…

• Severe asthma, which is defined as any of the following:
• Current (i.e. at the time of the visit) GINA Step 4 or higher therapy (medium dose ICS/LABA or high dose ICS or add-on LAMA; Medium dose = >250 fluticasone, propionate =100 fluticasone furoate, >200 beclomethasone, >400 budesonide, >220 mometasone). We will accept low-dose ICS/LABA or medium dose ICS.
• OR
• 3 or more unscheduled healthcare visits (provider/urgent care/ER) for asthma in the past 12 months OR
• One asthma hospitalization in the past 12 months
• History of any chronic lung disease other than asthma including but not limited to COPD, cystic fibrosis, pulmonary fibrosis, pulmonary hypertension
• Current pregnancy
• History of cancer other than non-melanoma skin cancer
• Diagnosed cardiovascular diseases (i.e., congenital heart disease, coronary heart disease)
• Inability to comply with study procedures, including
• Inability or unwillingness to provide informed consent
• Inability to perform study measurements
• Inability to be contacted by phone (via calls and/or text messaging) or email
• Any condition in the opinion of the physician that puts the participant at risk by participating in the study (e.g., serious respiratory illness requiring antibiotics or steroids or severe fever at the time of the study visit).
• Institutionalization

Where it is running

• Wake Forest School of Medicine — Winston-Salem, North Carolina, United States (enrolling)
• Ohio State University — Columbus, Ohio, United States (enrolling)
• Temple University — Philadelphia, Pennsylvania, United States (enrolling)
• University of Pittsburg-Emphysema/COPD Research Center — Pittsburgh, Pennsylvania, United States (enrolling)
• Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)
• Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)
• Baylor College of Medicine — Houston, Texas, United States (enrolling)
• University of Vermont — Colchester, Vermont, United States (enrolling)
• Northwestern University — Chicago, Illinois, United States (enrolling)
• University Of Alabama — Birmingham, Alabama, United States (enrolling)
• Rush Universtiy — Chicago, Illinois, United States (enrolling)
• University of California, Los Angeles — Los Angeles, California, United States (enrolling)
• University of California, San Francisco — San Francisco, California, United States (enrolling)
• University of Iowa — Iowa City, Iowa, United States (enrolling)
• University of Kansas — Kansas City, Kansas, United States (enrolling)
• Johns Hopkins University — Baltimore, Maryland, United States (enrolling)
• University of Arizona-Tuscon — Tucson, Arizona, United States (enrolling)
• University of Michigan — Ann Arbor, Michigan, United States (enrolling)
• National Jewish Health — Denver, Colorado, United States (enrolling)
• New York Medical College — Hawthorne, New York, United States (enrolling)
• Nemours Children's Jacksonville — Jacksonville, Florida, United States (enrolling)
• Mt. Sinai, NYC — New York, New York, United States (enrolling)
• University of Florida, Jacksonville — Jacksonville, Florida, United States (enrolling)
• Cornell University — New York, New York, United States (enrolling)
• University of Rochester — Rochester, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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