Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors
Stopped early · Phase 1
Conditions studied: Glioma, Glioma, Malignant, Glioma, Mixed, Glial Cell Tumors, Breast Cancer, Breast Carcinoma, Cancer of Breast, Cancer of the Breast, Breast Tumor, Malignant Tumor of Breast, Advanced Breast Cancer, Advanced Breast Carcinoma, Metastatic Breast Cancer, Metastatic Breast Carcinoma, Prostate Cancer, Prostatic Cancer, Cancer of Prostate, Cancer of the Prostate, Prostate Neoplasm, Castrate Resistant Prostate Cancer, Castration-resistant Prostate Cancer, Castration Resistant Prostatic Neoplasms, Glioblastoma, Recurrent Glioblastoma
In brief
At the time of study termination, NUV-422-02 was a first-in-human, open-label, Phase 1 dose escalation study designed to evaluate the safety and efficacy of NUV-422. The study population comprised adults with recurrent or refractory high-grade gliomas (HGGs), metastatic breast cancer (mBC), with and without brain metastases, and recurrent or refractory metastatic castration-resistant prostate cancer (mCRPC). All patients self-administered NUV-422 orally in 28-day cycles until disease progression, toxicity, withdrawal of consent, or termination of the study.
Key facts
- Study ID
- NCT04541225
- Run by
- Nuvation Bio Inc.
- People needed
- 74
- Starts
- 2020-12-08
- Expected to finish
- 2022-08-31
- Last updated by the study team
- 2023-07-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Oncology Associates — Tucson, Arizona, United States
- Miami Cancer Institute — Miami, Florida, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Carolina BioOncology Institute — Huntersville, North Carolina, United States
- Prisma Health Cancer Institute — Greenville, South Carolina, United States
- Texas Oncology P.A. Austin — Austin, Texas, United States
- Texas Oncology-Baylor Charles A. Sammons Cancer Center — Dallas, Texas, United States
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- Texas Oncology — Tyler, Texas, United States
- University of Utah Huntsman Cancer Institute — Salt Lake City, Utah, United States
- Virginia Cancer Specialists — Fairfax, Virginia, United States
Full record on ClinicalTrials.gov
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