Intraoperative Hyperoxia and MINS

Status unconfirmed

Conditions studied: Hyperoxia, Myocardial Infarction, Myocardial Injury

In brief

Oxygen therapy is administered to all patients during general anesthesia to maintain tissue oxygenation and prevent hypoxia and ischemia. However, liberal use of oxygen may lead to hyperoxia and some studies suggest that supranormal levels of arterial oxygen saturation may lead to complications. In this post hoc substudy of the VISION cohort, we plan to assess the association between perioperative inspired oxygen fraction (FiO2) and myocardial injury after non-cardiac surgery (MINS).

Key facts

Study ID

NCT04540276

Run by

University Hospital Bispebjerg and Frederiksberg

People needed

7700

Starts

2018-02-04

Expected to finish

2021-03-01

Last updated by the study team

2021-02-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients entered in the VISION database, aged 18 years or above, undergoing noncardiac surgery in general anesthesia.

You may not qualify if…

• Patients with unobtainable data on perioperative FiO2.
• Patients with unobtainable data on postoperative troponin.

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States
• Walter C. Mackenzie Health Sciences Centre — Edmonton, Canada
• Prince of Wales Hospital — Hong Kong, China
• Foundation CardioInfanil — Bogotá, Colombia
• Bispebjerg Hospital — Copenhagen, NV, Denmark
• Christian Medical College — Ludhiāna, India
• University Malaya Medical Centre — Kuala Lumpur, Malaysia
• Inkosi Albert Luthuli Hospital — Durban, South Africa

Full record on ClinicalTrials.gov

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