Precision Diagnosis and Prospective Cohort Study for Myasthenia Gravis: Multicenter Analysis in China
Recruiting now
Conditions studied: Myasthenia Gravis
In brief
The present study is a prospective cohort study aiming to improve the clinical capacity in the diagnosis and natural history of Chinese patients with myasthenia gravis (MG). 300 MG patients are planned to recruit, document and prospectively follow up. Management of screening test and cohort manifestation are studied.
Key facts
- Study ID
- NCT04535843
- Run by
- Huashan Hospital
- People needed
- 500
- Starts
- 2024-02-01
- Expected to finish
- 2028-05-01
- Last updated by the study team
- 2025-05-28
Who can join
Age: any, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- fluctuating muscle weakness and fatigability, along with one of the below:
- more than 10% amplitude decrement in low frequency repetitive nerve stimulation,less than 10% amplitude increment in high frequency repetitive nerve stimulation;
- anti-AChR or MuSK antibody positivity;
- positive to the neostigmine test;
- understanding and assigning the informed consent form, and having a good compliance with the follow up.
You may not qualify if…
- excluding the possible diagnosis of Lambert-Eaton syndrome, congenital myasthenia syndrome,botulism injection, chronic progressive extraocular ophthalmoplegia, etc;
- poor compliance to the follow up.
Where it is running
- Shanghai Chest Hospital — Shanghai, Shanghai Municipality, China (enrolling)
- Obsterics and Gynecology Hospital of Fudan University — Shanghai, Shanghai Municipality, China (enrolling)
- Children's Hospital of Fudan University — Shanghai, Shanghai Municipality, China (enrolling)
- Huashan Hospital — Shanghai, China (enrolling)
Full record on ClinicalTrials.gov
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