Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Repeated Implantation Failure
In brief
The randomized, placebo-controlled multicenter trial is conducted in five centers in China. After screening and obtaining the signed informed consent , the participants are randomly divided into three groups: acupuncture group (Acu.+IVF），sham acupuncture group（Sham Acu. +IVF），and the control group (only IVF).
Key facts
- Study ID
- NCT04533295
- Run by
- Huazhong University of Science and Technology
- People needed
- 771
- Starts
- 2020-11-02
- Expected to finish
- 2027-09-01
- Last updated by the study team
- 2026-03-10
Who can join
Age: 25 and older, up to 40. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Married women aged 25-40;
- Repeated implantation failure for unknown reasons (experienced 2 or more embryo transfers of good-quality embryos without achieving clinical pregnancy);
- Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (≥3BB);
- Estrogen and progesterone replacement therapy (HRT), endometrial thickness ≥7mm on the day of endometrial transformation.
You may not qualify if…
- Patients who met any of the following conditions were not included.
- Those who prepare for PGD;
- Recipients of egg donors;
- Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism);
- patients with implantation failure due to known embryonic factors;
- Uterine lesions that may affect implantation (including uterine malformation, >4cm intramural fibroids，submucosal fibroids, adenomyosis, uterine tuberculosis, intrauterine adhesions, etc.
- Repeated spontaneous abortion (2 or more fetal loss before 28 weeks of gestation);
- Patients with other endocrine diseases, such as thyroid disease, hyperprolactinemia, insulin resistance, diabetes, adrenal disease, etc., and poor control of hormone levels in the last 3 months;
- Clearly diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, etc.;
- Hydrosalpinx untreated;
- BMI less than 18 or higher than 25kg/m2;
- People with previous history of needle sickness;
- Those who have previously participated in this study or received acupuncture treatment in the past 3 months.
- Any situation that researchers consider inappropriate for participating in this study.
Where it is running
- Tongji Hospital,Tongji medical college,HUST — Wuhan, Hubei, China (enrolling)
Full record on ClinicalTrials.gov
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