Hand Sanitizer Effects on the Skin Barrier

Status unconfirmed

Conditions studied: Dermatitis Hand, Skin Abnormalities, Atopic Dermatitis, Atopic Dermatitis Eczema

In brief

Hand washing and the use of hand sanitizers are important interventions in disease prevention. Engaging in frequent hand washing is especially effective in preventing the spread of viruses, as this removes microbes and prevents the spread to others. Hand dermatitis, however, is a common occurrence in certain occupations, such as healthcare workers. With the onset of the SARS-CoV2 (COVID-19) pandemic, hand hygiene measures are further enforced as there is no cure or vaccine for this virus. In the study, the effects of hand washing and the use of hand sanitizer on skin proteins and lipids will be assessed.

Key facts

Study ID

NCT04525521

Run by

National Jewish Health

People needed

40

Starts

2020-12-01

Expected to finish

2021-08-20

Last updated by the study team

2021-03-02

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion criteria of the AD group:
• Individuals with atopic dermatitis, ages 18-60 years old.
• Inclusion criteria of the non-atopic group, ages 18-60 years old:
• Individuals with no history of atopic dermatitis, contact dermatitis, food allergy, asthma, or allergic rhinitis.

You may not qualify if…

• Exclusion criteria of all subjects:
• Subject has taken systemic immunosuppressive drugs including oral steroids within 30 days of skin barrier assessment
• Subject has received immunotherapy in the past year
• Subject has received any biologic medications within 5 half-lives or 16 weeks, whichever is longer
• Subject has received any investigational drugs within 5 half-lives or 8 weeks, whichever is longer
• Subject has taken anti-anxiety, antidepressant, or anticoagulant medications in the last 30 days
• Subject has received total body phototherapy (e.g., ultraviolet light B [UVB], psoralen plus ultraviolet light A [PUVA], tanning beds [>1 visit per week]) within 30 days of skin barrier assessment
• Subject has used topical corticosteroids, topical immunomodulatory agents, or topical antibiotics on the extremity being evaluated within 7 days of skin barrier assessment
• Subject has a severe concurrent disease or immunosuppression
• Subject has a history of a severe reaction to latex, tape, or adhesives
• Subject is pregnant or lactating
• For the medications below, they have to be temporarily withheld before participation in the study:
• If the subject is taking oral antihistamines, they will need to be withheld for five days prior to the skin barrier study.
• If the subject is taking oral antibiotics, antivirals, antifungals, or antiparasitics, the skin barrier studies can be scheduled seven days after the last dose has been taken.
• If the subject is taking topical medications including (but not restricted to) Elidel, Protopic, topical corticosteroids and topical antibiotics, they will need to be withheld on the hand being evaluated seven days prior to the skin barrier studies. Moisturizers will also need to be withheld on the area 24 hours prior to the visit. The subject cannot have taken a bleach bath within 7 days of the visit, and the subject cannot take a bath or shower on the day of the visit.

Where it is running

• National Jewish Health — Denver, Colorado, United States (enrolling)

Full record on ClinicalTrials.gov

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