The Utility of Thromboelastography in Traumatic Brain Injury

Recruiting now

Conditions studied: Traumatic Brain Injury, Coagulation Disorder

In brief

Hemocoagulation disorder is recognized to have crucial effects on hemorrhagic or ischemic diseases. Coagulation-related damages secondary to traumatic brain injury are common and severe secondary insults of head trauma and often leads to a poor prognosis. In this study, we sought to assess if posttraumatic hemocoagulation disorders determined using thromboelastography are associated with coagulation-related damages secondary to traumatic brain injury, and evaluate their influence on outcome among patients with head trauma. Based on above results, prediction models or risk scoring systems will be further developed and validated to predict coagulation-related damages secondary to traumatic brain injury.

Key facts

Study ID

NCT04524637

Run by

Shanghai 6th People's Hospital

People needed

500

Starts

2018-09-01

Expected to finish

2027-12-31

Last updated by the study team

2025-03-17

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who are delivered to hospital within 24 hours after head trauma
• Patients whose abbreviated injury score (AIS) for other body regions is 3 or less are considered to be isolated traumatic brain injury

You may not qualify if…

• Patients with existing prior neurological disease
• Patients with known coagulation disorders
• Patients on anticoagulants and medications known to affect coagulation function within 30 days before trauma
• Patients receiving blood components prior to blood draw
• Patients who deteriorate and die before determining whether coagulation- related damage exists

Where it is running

• Shanghai Sixth People's Hospital — Shanghai, China (enrolling)

Full record on ClinicalTrials.gov

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