Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure

Recruiting now · Not applicable

Conditions studied: Respiratory Insufficiency, Neuromuscular Blockade, Mechanical Ventilation

In brief

PNEUMA is a preliminary safety and feasibility trial of a novel approach to the titration of neuromuscular blockade (NMB) to safe spontaneous breathing in patients with moderate to severe acute hypoxemic respiratory failure (AHRF) supported with invasive mechanical ventilation.

Key facts

Study ID

NCT04524585

Run by

University Health Network, Toronto

People needed

23

Starts

2020-10-01

Expected to finish

2027-03-01

Last updated by the study team

2026-01-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients supported on invasive mechanical ventilation for moderate to severe AHRF (PaO2/FiO2 < 150 mm Hg or FiO2 ≥ 60% with an SpO2 ≤ 97% or receiving venovenous extracorporeal membrane oxygenation)

You may not qualify if…

• Contraindication to neuromuscular blockade (allergy, history of malignant hyperthermia)
• Contraindication to ulnar nerve stimulation (bilateral peripheral neuropathy, skin burns on both wrists)
• Previous history of a formally diagnosed neuromuscular disorder

Where it is running

• University Health Network — Toronto, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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