Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Recruiting now
Conditions studied: Postoperative Delirium, Postoperative Cognitive Dysfunction, Thoracic Aortic Aneurysm
In brief
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery. The aim of this study is to identify and unravel the biochemical (neuroinflammatory) pathways involved in postoperative delirium. Patient undergoing thoracic aortic surgery will have an external lumbar drain (ELD) in situ on the day before surgery. This ELD remains in place during and three days after surgery to reduce the risk on periprocedural spinal cord ischemia. Paired measurements of CSF and blood will be analyzed.
Key facts
- Study ID
- NCT04523909
- Run by
- Radboud University Medical Center
- People needed
- 100
- Starts
- 2017-12-18
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2023-03-31
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Competent patients ≥ 18 years
- Patients who will undergo thoracic aortic surgery and will therefore receive an external lumbar drain as a standard of care procedure.
You may not qualify if…
- Patients with meningitis/encephalitis/brain abscess within the last 6 months
- Patients with other neurological conditions: brain injury (acute stroke, brain trauma or cerebral haemorrhage) within the last 3 months, known brain tumours, neurodegenerative disease or known pre-existing cognitive impairment (to a degree that would be compatible with mild cognitive impairment or more).
- Brain or spinal surgery within the last 3 months
- Active infection <2 weeks before surgery
- Patients who object against storage of their body material for scientific reasons
Where it is running
- Department of Intensive Care Medicine, Radboud university medical center — Nijmegen, Netherlands (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.