Tailored Non-Pharmacotherapy Services for Chronic Pain

Completed · Not applicable

Conditions studied: Chronic Pain

In brief

The RESOLVE study is a multicenter comparative effectiveness trial of two cognitive behavioral therapy-based chronic pain (CBT-CP) treatments delivered via telehealth modalities: 1) online program and 2) live, health coach-led, virtual sessions (telephone and/or video conference).

Key facts

Study ID: NCT04523714
Run by: Kaiser Permanente
People needed: 2333
Starts: 2021-01-14
Expected to finish: 2025-08-31
Last updated by the study team: 2026-01-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Electronic Health Record-based inclusion criteria:
Active/enrolled in one of the 4 participating integrated health care systems at the time of query and for the prior 360 days
Age 18 years or older (based on date of birth documented in EHR)
English speaking or do not need interpreter services
Have at least one [at Essentia] or at least two which are >60 days apart [at KP sites] outpatient pain-related health care encounter with nonmalignant musculoskeletal pain diagnoses [as determined by ICD10 codes for any of the following: back-neck-, limb/extremity-, joint-pain, arthritic disorders, fibromyalgia, headache, orofacial/temporomandibular pain, or musculoskeletal pain] within the past 360 days
Do not have an encounter for surgery related to common musculoskeletal pain conditions (e.g., joint replacement, spinal fusion, carpal tunnel release surgery) [as determined by CPT and/or ICD-10 codes] within the past 60 days
Do not have two or more separate encounters with a malignant cancer diagnosis other than non-melanoma skin cancer [as determined by ICD-10 codes] within past 60 days
Do not have ICD-10 code(s), Current Procedural Terminology (CPT) code(s) or department/provider encounters indicating receipt of hospice or other palliative care within the past 360 days
Do not have ICD-10 codes indicating severe cognitive impairment precluding participation in a behavioral/ lifestyle change program
Note: At the KPWA site only, one additional EHR-based exclusion criterion will be applied, which is: Do not have ICD-10 codes indicating opioid use disorder (OUD). This criterion is being applied because there is another HEAL study being conducted at KPWA that focuses on treating individuals with pain and OUD specifically.]
Patient-reported inclusion criteria:
Have high-impact chronic pain (as indicated by self-report of having pain on most or every day in past 3 months and pain limiting life or work activities on most or every day in past 3 months)
Have persistent pain (as indicated by self-report Pain, Enjoyment of Life and General Activity (PEG) score of ≥ 12)
Be able to participate in either of the active interventions (i.e., have internet and phone access required for accessing treatments)
EXCLUSION CRITERIA (patient-reported):
Have received CBT for pain or pain-related psychoeducation or behavioral skills training within in the past 6 months (in-person, by phone or videoconference, or online)
Currently receiving or will be starting CBT for pain or pain-related psychoeducation or behavioral skills training in the next month (in-person, by phone or videoconference, or online)
Currently receiving or will be starting inpatient or intensive outpatient services for substance use disorder in the next month
Have a planned/scheduled surgery in next 12 months related to pain condition

Where it is running

Kaiser Permanente Georgia, Center for Research and Evaluation — Atlanta, Georgia, United States
Essentia Institute of Rural Health — Duluth, Minnesota, United States
Kaiser Permanente Northwest Center for Health Research — Portland, Oregon, United States
Kaiser Permanente Washington Health Research Institute — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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