Dumping Syndrome and Esophageal Atresia

Recruiting now · Not applicable

Conditions studied: Oesophageal Atresia, Dumping Syndrome

In brief

Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood. This is also an affection difficult to diagnose, because it only occurs after meals and can be inconstantly present. To date, their is only symptomatic treatment for DS. This study aims to understand its pathological mechanisms so as to better treat it and avoid its consequences. Oesophageal atresia patients enrolled in this study will benefit from a continuous glycemic monitoring, a continuous cardiac monitoring, and an a gastric emptying scintigraphy at the age of 3 months

Key facts

Study ID

NCT04522193

Run by

University Hospital, Lille

People needed

15

Starts

2024-02-23

Expected to finish

2026-11-01

Last updated by the study team

2025-12-23

Who can join

Age: 0 and older, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients operated at birth for Oesophageal atresia type C
• Aged from 2 to 3 months at inclusion
• Off prokinetic treatment (suspended for at least 72 hours) before monitoring

You may not qualify if…

• History of dumping syndrome of other cause (microgastria, fundoplication, dysautonomia..)
• History of any disease that can modify glycemic regulation (hyperinsulinism, neonatal diabete)
• Treatment that can modify gastric motility

Where it is running

• Hôpital Jeanne de Flandre - Pôle enfant, CHU de Lille — Lille, France (enrolling)
• Hôpital Jeanne de Flandres — Lille, France

Full record on ClinicalTrials.gov

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