Effects of 5HTP on the Injured Human Spinal Cord
Recruiting now · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Spinal Cord Injuries
In brief
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs in a randomized, double-blinded, placebo-controlled crossover design.
Key facts
- Study ID
- NCT04520178
- Run by
- University of Alberta
- People needed
- 30
- Starts
- 2020-07-01
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2025-08-27
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- participants must have suffered trauma to the spinal cord at least six months ago or longer
You may not qualify if…
- individuals with damage to the nervous system other than to the spinal cord
- pregnant and/or breastfeeding women
- alcoholic participants
- history of seizure/epilepsy
- history of suicidal thoughts or behaviors
- known or suspected allergy to the medication ingredients
- cardiovascular disease including history of heart attack or heart rhythm irregularities
- coronary artery disease
- reduced liver function or disease
- reduced kidney function or disease
- lung disease
- comatose or depressed states due to CNS depressants
- endocrine dysfunction
- blood dyscrasias or blood related disease
- bone marrow depression
- hypocalcemia
- history of stomach ulcers
- wide angle glaucoma
- phenylketonuria
- history of tumors
- uncontrolled heart problems
- unstable psychiatric or mental disorder
- Participants taking:
- monoamine oxidase inhibitor therapy
- serotonergic antidepressants
Where it is running
- University of Alberta — Edmonton, Alberta, Canada (enrolling)
- University of Louisville — Louisville, Kentucky, United States
Full record on ClinicalTrials.gov
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