CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids

Stopped early

Conditions studied: Asthma, Bone Density, Low, Oral Steroid-Dependent Asthma (Disorder)

In brief

The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density, micro-structure, and marrow adipose tissue (MAT) among patients treated with oral steroids.

Key facts

Study ID

NCT04518722

Run by

University of Iowa

People needed

2

Starts

2020-12-01

Expected to finish

2021-09-28

Last updated by the study team

2026-04-07

Who can join

Age: 25 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion (all subjects):
• Diagnosis of severe, persistent asthma (defined as using both a long-acting beta-agonist AND a high-dose inhaled steroid)
• Age 25-45
• Inclusion (oral steroid group):
• Chronic treatment with oral steroids for at least 45 days but less than 1 year

You may not qualify if…

• Exclusion (all subjects):
• Pregnant or breastfeeding
• History of any cancer, excluding non-melanoma skin cancer
• Currently receiving dialysis
• History of any lower extremity fracture
• Hip or knee replacement
• Non-ambulatory
• Greater than 10 pack-year smoking history
• BMI > 50
• Age < 25 or > 45
• Current or past use of FDA-approved medication for osteoporosis:
• Bisphosphonates (Alendronate/Fosamax, Ibandronate/Boniva, Risedronate/Actonel/Atelvia, Zoledronic Acid/Reclast) Calcitonin (Fortical, Miacalcin) Selective Estrogen Receptor Modulator (Raloxifene/Evista) Parathyroid Hormone Analogue (Teriparatide/Forteo) Monoclonal Antibody (Denosumab/Prolia)

Where it is running

• University of Iowa — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.