Total Intravenous Anesthesia and Recurrence Free Survival

Recruiting now · Phase 3

Conditions studied: Esophageal Cancer

In brief

The investigators propose to compare recurrence-free survival in patients having potentially curative (Stages 1-3) surgery for esophageal cancer who will be randomly assigned to propofol-based total intravenous anesthesia or sevoflurane-based balanced general anesthesia.

Key facts

Study ID

NCT04513808

Run by

The Cleveland Clinic

People needed

1614

Starts

2020-08-15

Expected to finish

2027-12-01

Last updated by the study team

2024-12-04

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Primary esophageal cancer without known extension beyond the esophagus. (i.e. believed to be Tumor Stage 1-3).
• Scheduled for potentially curative esophageal cancer surgery.
• Written informed consent, including willingness to be randomized to intravenous versus volatile anesthesia.

You may not qualify if…

• Previous surgery for esophageal cancer (except diagnostic biopsies) Age <18 or >85 years old.
• ASA Physical Status ≥4.
• Any contraindication to propofol or sevoflurane.
• Other cancer not believed by the attending surgeon to be in long-term remission.
• Systemic disease believed by the attending surgeon to present ≥25% two- year mortality.

Where it is running

• Shanhai Chest Hospital — Shanghai, China (enrolling)

Full record on ClinicalTrials.gov

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