Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse

Completed · Phase 2 · Has a placebo group

Conditions studied: Dental Plaque, Dental Caries

In brief

This study aims to investigate the impact of a bromelain pre-rinse adjunct on oral plaque removal in orthodontic subjects. The study's null hypothesis states that there is no statistically significant difference in visual plaque scores among orthodontic subjects with or without proteolytic enzyme rinse aid.

Key facts

Study ID

NCT04512482

Run by

Indiana University

People needed

46

Starts

2018-06-14

Expected to finish

2019-03-04

Last updated by the study team

2020-12-03

Who can join

Age: 10 and older, up to 25. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• male or female
• 10 to 25 years of age
• willing to consent to participation
• able to follow study instructions
• in active orthodontic treatment with fixed orthodontic appliances

You may not qualify if…

• unwilling/unable to follow study instructions
• documented/suspected pineapple allergy
• proteolytic enzyme allergy
• food dye allergy
• smoker

Where it is running

• Indiana University School of Dentistry — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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