Childhood Cancer Predisposition Study (CCPS)

Recruiting now

Conditions studied: Pediatric Cancer

In brief

The Childhood Cancer Predisposition Study (CCPS) is a multi-center, longitudinal, observational study that will collect clinical and biological data and specimens from children with a cancer predisposition syndromes (CPS) and their relatives. The central hypothesis is that studying individuals at high risk for childhood cancer creates a unique opportunity for improving the understanding of carcinogenesis, tumor surveillance, early detection, and cancer prevention, which will collectively contribute to improving care and outcomes for pediatric patients with cancer and those with cancer predisposition syndromes (CPS).

Key facts

Study ID

NCT04511806

Run by

Emory University

People needed

1050

Starts

2021-04-22

Expected to finish

2030-10-01

Last updated by the study team

2025-10-29

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Primary Subjects must meet all of the below criteria to be eligible for enrollment:
• Be less than 21 years of age at the time of enrollment
• Have a diagnosis of a specific CPS, whether they have had cancer or not
• Based on clinical laboratory testing demonstrating a Pathogenic or Likely Pathogenic germline variant and/or
• Based on well-established clinical diagnostic criteria and/or
• Based on high clinical suspicion of a specific CPS with clinical laboratory testing demonstrating a variant of uncertain significance (VUS)
• Affected Parents must meet all of the following criteria to be eligible for enrollment:
• Be the biologic parent of a Primary Subject and
• Carry a diagnosis (or obligate diagnosis) of the familial CPS
• Adult Affected Siblings must meet all of the following criteria to be eligible for enrollment:
• Be the biologic sibling of a Primary Subject and
• Carry a diagnosis (or obligate diagnosis) of the familial CPS
• Unaffected Parents and Siblings must meet all of the following criteria to be eligible for enrollment
• Be the biologic parent or sibling of a Primary Subject and
• Not carry a diagnosis (or obligate diagnosis) of the familial CPS
• Affected Family Members must meet all of the following criteria to be eligible for enrollment:
• Carry a diagnosis of (or obligate diagnosis of) the familial CPS. Documentation is requested but not required.
• More than one child from a Primary Family Unit may be a Primary Subject. An Unaffected Sibling may be reclassified as a Primary Subject if diagnosed with a CPS during childhood.

You may not qualify if…

• Individuals with a strong personal or family history of cancer without a genetic or clinical diagnosis of a specific CPS are not eligible for enrollment.

Where it is running

• Children's Healthcare of Atlanta (CHOA) — Atlanta, Georgia, United States (enrolling)
• Dana Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)
• St. Jude Children's Research Hospital — Memphis, Tennessee, United States (enrolling)
• Baylor College of Medicine — Houston, Texas, United States (enrolling)
• Primary Children's Hospital — Salt Lake City, Utah, United States (enrolling)
• Hospital for Sick Children — Toronto, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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