RAAS and Arterial Stiffness in SCI

Completed

Conditions studied: Arterial Stiffness, Renin Angiotensin Aldosterone System, Orthostatic Hypotension, Spinal Cord Injury, Hypotension

In brief

The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.

Key facts

Study ID

NCT04510974

Run by

James J. Peters Veterans Affairs Medical Center

People needed

33

Starts

2018-06-30

Expected to finish

2020-12-01

Last updated by the study team

2025-02-20

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• SCI participants:
• injured between C1-T1 and T6-T12
• wheelchair dependent
• AIS classification A, B or C
• Injured occurred more than 1 year ago

You may not qualify if…

• currently have an illness or infection
• current smoker of at least 1 year
• controlled or uncontrolled hypertension or diabetes mellitus
• Neurological condition other than SCI (Alzheimer's disease, dementia, stroke, multiple sclerosis, Parkinson's disease)
• cardiovascular disease (coronary heart disease, congestive heart failure, peripheral artery disease)

Where it is running

• James J Peters VAMC — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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