Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease

Recruiting now

Conditions studied: Inflammatory Bowel Disease, Crohn Disease

In brief

The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. This longitudinal project will focus on abnormalities in bone marrow composition, and specifically whether adolescents with newly diagnosed CD exhibit increased bone marrow fat, its association with bone mineral density (BMD) and the underlying pathophysiology, including bone turnover markers and immune cellular/molecular parameters.

Key facts

Study ID

NCT04508088

Run by

Massachusetts General Hospital

People needed

92

Starts

2020-09-10

Expected to finish

2026-12-01

Last updated by the study team

2025-10-30

Who can join

Age: 13 and older, up to 20. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Crohn's Disease diagnosed within the past 3 months, or a healthy, matched control

You may not qualify if…

• Participants with chronic disease known to affect skeletal metabolism
• Participants on certain medications within the prior 3 months that are known to affect skeletal metabolism
• Participants who are pregnant
• Participants who have a history of: claustrophobia, internal body metal that is not compatible with MRI machine, or a known abnormality on or adjacent to the left knee

Where it is running

• Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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