High Flow Nasal Cannula With Noninvasive Ventilation
Completed · Not applicable
Conditions studied: Acute Respiratory Failure
In brief
This is a prospective, randomized, unblinded trial of trauma patients in the ICU who are identified as being at a high risk to develop acute respiratory failure. We hope that this study will help the study team to identify how best to use a more aggressive respiratory treatment strategy in a high risk trauma population (thoracic trauma or trauma patients requiring thoracic surgery, spine surgery, or open abdominal procedures) to try and decrease the need for intubation with mechanical ventilation.
Key facts
- Study ID
- NCT04507425
- Run by
- University of Oklahoma
- People needed
- 6
- Starts
- 2020-09-01
- Expected to finish
- 2023-07-10
- Last updated by the study team
- 2023-11-21
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults at least 18 years of age
- Admission to an intensive care unit by the trauma surgery service
- Trauma patients receiving any respiratory therapies
- High risk patients, including intubation, post-operative, chronic cardiac or pulmonary comorbidities
- Thoracic injuries, including rib fractures, sternal fractures, spinal fractures, pulmonary contusions, pneumothorax, hemothorax, diaphragm injury
- Postoperative from thoracic surgery
- Postoperative from spine surgery in patients without spinal cord injury
- Abdominal injuries requiring open abdominal surgery
- No contraindications to using high flow nasal cannula or noninvasive ventilation
You may not qualify if…
- Contraindication to using high flow nasal cannula or noninvasive ventilation
- Intolerance of pulmonary therapies
- No one able to give informed consent
- Long-term treatment with noninvasive ventilation prior to hospital admission
- "Do not intubate" order at time of extubation
- Unplanned extubation (accidental or self-extubation)
- Age < 18 years of age
- Traumatic brain injury with GCS < 8
- Spinal cord injury
- Chronic neuromuscular disease
- Sinus precautions due to facial/sinus fractures
Where it is running
- OU Medical Center — Oklahoma City, Oklahoma, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.