Cardiac Rehab Effects in HFpEF

Running, not enrolling · Not applicable

Conditions studied: Heart Failure With Preserved Ejection Fraction

In brief

This research in Veterans with heart failure with preserved ejection fraction (HFpEF) will provide new information on the mechanisms determining the patients' exercise intolerance and the efficacy of regular physical activity to improve this shortcoming by alleviating the patients' neurocirculatory abnormalities. Specifically, the investigators will focus on the role of nerves originating in working limb muscles in determining the patients' exercise intolerance and compromised fatigue resistance before and after a chronic exercise intervention. By focusing on a specific mechanism, this project will evaluate the validity of exercise as an alternative treatment strategy with the overall purpose of improving the quality of life of Veterans with HFpEF.

Key facts

Study ID
NCT04506606
Run by
VA Office of Research and Development
People needed
45
Starts
2022-05-02
Expected to finish
2026-09-30
Last updated by the study team
2026-03-19

Who can join

Age: 21 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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