Genetic Mechanisms Underlying SARS-CoV-2 Infection and the Impact of COVID-19 on Cognitive Function

Status unconfirmed

Conditions studied: Covid19

In brief

There is a considerable variation in the disease behavior in terms of contracting the infection, manifesting none to a range of symptoms and severity of the infection among individuals exposed to or infected with SARS-CoV-2 virus, the causative organism of COVID-19. Although the respiratory system appears to be the primary target of this virus infection, emerging evidences suggests involvement of extra-pulmonary organs including central nervous system. We aim to compare the genetic profile of individuals with vs without COVID-19 after being exposed to infected cases. Additionally, we will assess the cognitive function in covid-19 positive cases with vs. without neurological symptoms at the time of infection and 1-month follow-up using the Montreal Cognitive Assessment (MoCA) questionnaire.

Key facts

Study ID

NCT04506229

Run by

Texas Cardiac Arrhythmia Research Foundation

People needed

60

Starts

2020-08-20

Expected to finish

2021-09-01

Last updated by the study team

2020-08-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female over 18 years of age at the time of enrollment
• Have symptoms of COVID-19 (with or without hospitalization) or contact history
• Willing to undergo nasopharyngeal swab test for viral-RNA at baseline (in non-hospitalized cases) and the MoCA survey at baseline and 1-month follow-up

You may not qualify if…

• Unwilling to provide informed consent
• MoCA score ≤17 at baseline
• Patients with clinical diagnosis of dementia
• Impaired consciousness

Where it is running

• Texas Cardiac Arrhythmia Institute — Austin, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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