A Dose Escalation/Expansion Study of Oral OP-1250 in Subjects With Advanced and/or Metastatic HR+, HER2- Breast Cancer
Completed · Phase 1/Phase 2
Conditions studied: Hormone Receptor Positive Breast Carcinoma, HER2-negative Breast Cancer
In brief
This clinical trial is a Phase I dose escalation and dose expansion and Phase II monotherapy open-label, first-in-human, multicenter study of OP-1250 in adult subjects with advanced and/or metastatic hormone receptor (HR)-positive, her2-negative breast cancer.
Key facts
- Study ID
- NCT04505826
- Run by
- Olema Pharmaceuticals, Inc.
- People needed
- 153
- Starts
- 2020-08-13
- Expected to finish
- 2024-07-30
- Last updated by the study team
- 2026-05-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UCLA Hematology/Oncology — Los Angeles, California, United States
- University of Colorado — Aurora, Colorado, United States
- University of Miami, Sylvester Comprehensive Cancer Center — Deerfield Beach, Florida, United States
- Advent Health — Orlando, Florida, United States
- Florida Cancer Center — Sarasota, Florida, United States
- Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center — Indianapolis, Indiana, United States
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Saint Luke's Hospital of Kansas City — Kansas City, Missouri, United States
- Montefiore Medical Center — The Bronx, New York, United States
- Cleveland Clinic Taussig Cancer Center — Cleveland, Ohio, United States
- Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
- Providence Portland Medical Center — Portland, Oregon, United States
- OHSU Knight Cancer Institute — Portland, Oregon, United States
- Sarah Cannon Research Institute — Nashville, Tennessee, United States
- Macquarie University — Sydney, New South Wales, Australia
- Westmead — Westmead, New South Wales, Australia
- ICON Cancer Centre — Auchenflower, Queensland, Australia
- Cancer Research South Australia — Adelaide, South Australia, Australia
Full record on ClinicalTrials.gov
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