Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation
Completed · Not applicable · Has a placebo group
Conditions studied: Suicidal Ideation, Major Depressive Disorder
In brief
The purpose of this study is to gather information regarding the use of a new type of transcranial magnetic stimulation (TMS) called theta burst stimulation (TBS) for suicidal ideation in adolescents with Major Depressive Disorder (MDD). The investigators hope to learn if this TMS treatment improves suicidal ideation over 10 days and clinical outcomes over 1 year of follow-up.
Key facts
- Study ID
- NCT04502758
- Run by
- Mayo Clinic
- People needed
- 58
- Starts
- 2022-04-04
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2026-08-05
Who can join
Age: 12 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Inpatients or outpatients
- Voluntary clinical patient with the capacity to assent to treatment and a parent or legal guardian with the capacity to consent
- Female or male
- 12-18 years of age
- Diagnosed with MDD based on Diagnostic and Statistical Manual for Mental Disorders, 5th edition (DSM-5) criteria122 with the Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI Kid) in subjects 12-17 years of age;118 The Mini-International Neuropsychiatric Interview will be used for subjects who are 18 years of age117
- In a current episode of MDD with duration of at least 4 weeks but less than 3 years
- Depressive symptom severity as demonstrated by CDRS-R total composite score of 40 or greater and a suicidal ideation score of 3 or more on item 13 of the CDRS-R109
- Demonstrating that depressive symptom severity as evaluated at the screening visit does not improve between screening and baseline by 25% or more
- Eligible for transcranial magnetic stimulation (TMS) based on safety criteria104
- On a medically acceptable form of birth control if female
- Taking an antidepressant medication if recommended by the referring clinician and agreed upon by parents and patients. Please note that patients are not required to take an antidepressant medication for study participation for practical, ethical, and human subject protection concerns. Medication status and prior treatment resistance will be carefully recorded with the Antidepressant Treatment History Form113 criteria for relevant statistical considerations.
You may not qualify if…
- Diagnosis of a psychotic disorder, bipolar disorder, anorexia nervosa, bulimia nervosa, substance use disorders within the past year (with the exception of caffeine and tobacco).
- Intelligent quotient less than 70 (if there is a clinical concern, subjects will be psychometrically assessed with the Slosson Intelligence Test, Revised).123
- Positive urine drug screen at baseline
- Seizure history
- Any family history of epilepsy
- History of any treatment with electroconvulsive therapy or TMS
- Use of any investigational drug within 4 weeks of baseline
- Prior brain surgery
- Risk for increased intracranial pressure such as a brain tumor
- Head trauma with loss of consciousness
- Any true positive findings on the TMS safety screening form
- Pregnancy or suspected pregnancy
- Conductive, ferromagnetic, or other magnetic-sensitive metals implanted in the head-within 30 cm of the treatment coil excluding the mouth that cannot be safely removed (examples include cochlear implants, vagus nerve stimulators, deep brain stimulators, implanted electrodes/stimulators, aneurysm clips or coils, stents, bullet fragments, jewelry and hair barrettes).
- Implanted medication pumps and cardiac pacemakers
- Any unstable medical condition
- Inability to adhere to the protocol
Where it is running
- Mayo Clinic in Rochester — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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