Heterogeneity of Critical Illness: a Cohort Study

Recruiting now

Conditions studied: Critically Ill, Organ Failure, Multiple

In brief

Rationale: There is large heterogeneity in disease states of critically ill patients at ICU admittance and there is also large heterogeneity in their disease severity during ICU stay. Still, some patients may show remarkable similarities in disease patterns. There is a lack of understanding of causal mechanisms that lead to divergent outcomes in critically ill patients, and at the same time different diseases may share common underlying, yet unidentified, causal pathways that could explain similarities between different diseases. Objective: To explore the association between patient characteristics and the severity of organ failure in critically ill patients admitted to the ICU Study design: Prospective cohort study Study population: Adult critically ill patients in the ICU Intervention (if applicable): not applicable Main study parameters/endpoints: Maximum severity of organ failure observed during ICU stay measured by the maximum SOFA score and quality of life at one year follow-up

Key facts

Study ID

NCT04502511

Run by

University Medical Center Groningen

People needed

5000

Starts

2022-01-01

Expected to finish

2030-01-01

Last updated by the study team

2026-05-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults Definition: age ≥18 years.
• Emergency admission to the ICU Definition: patients who are acutely admitted to the ICU due to acute or unexpected critical illness, either from the emergency department or the ward or transferred from an ICU (or a ward) from another hospital.

You may not qualify if…

• Planned admission
• Absence of an invasive arterial or venous line for blood sampling.
• Any continued cardiopulmonary resuscitation efforts upon admission which limit access to the patient for research activities.
• Main ICU admission reason chronic (non-invasive) home ventilation
• Main ICU admission reason normothermic treatment after cardiac arrest
• Main ICU admission reason ischemic stroke, intracerebral bleeding, or isolated neurotrauma
• Main ICU admission reason Coronavirus Disease 2019 (COVID-19)
• Solid organ or hematopoietic stem cell transplant during current hospital admission
• Strict isolation due to any contagious disease
• No informed consent

Where it is running

• University Medical Center Groningen — Groningen, Provincie Groningen, Netherlands (enrolling)

Full record on ClinicalTrials.gov

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