Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

Recruiting now · Not applicable

Conditions studied: Supine Hypertension, Autonomic Failure

In brief

Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective at lowering supine blood pressure, these approaches may be utilized to treat supine hypertension non-pharmacologically. Raising the head of the bed decreases the amount of blood returning to the heart due to the effects of gravity. In this case, the decreased blood return to the heart may decrease blood pressure.

Key facts

Study ID

NCT04502225

Run by

Vanderbilt University Medical Center

People needed

44

Starts

2020-08-21

Expected to finish

2026-12-31

Last updated by the study team

2025-11-06

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with autonomic failure and with supine hypertension from all races
• Males and females, between 18 to 85 years

You may not qualify if…

• All medical students
• Pregnant women
• High-risk patients (for example: heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction)
• History of serious allergies or asthma.

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

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