A Phase 2 Study Evaluating the Safety and Efficacy of Netarsudil Ophthalmic Solution in Patients With Corneal Edema Due to Fuchs Corneal Dystrophy

Completed · Phase 2

Conditions studied: Corneal Edema

In brief

Two different dosing regimens (QD and BID) of netarsudil will be studied to evaluate their efficacy in reducing or resolving corneal edema in subjects with FCD.

Key facts

Study ID

NCT04498169

Run by

Aerie Pharmaceuticals

People needed

40

Starts

2020-09-17

Expected to finish

2021-08-11

Last updated by the study team

2022-09-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 years or older
• Documented diagnosis of FCD
• Evidence of central corneal edema, in at least one eye, at the Screening and Baseline Visit, in the eligible eye(s)
• Reduced BCVA secondary to central corneal edema, at Screening and Baseline, in the eligible eye(s)

You may not qualify if…

• FCD so advanced that, in the opinion of the Investigator, surgery would likely be required in the study eligible eye(s) within the study period
• Clinically significant ocular disease (other than FCD) or trauma in the eligible eye(s) which could interfere with study interpretation
• History of ocular surgery within 6 months of the Screening Visit, or any prior corneal refractive surgery in the eligible eye(s)

Where it is running

• Orange County Ophthalmology — Garden Grove, California, United States
• Harvard Eye Associates — Laguna Hills, California, United States
• Cincinnati Eye Institute — Edgewood, Kentucky, United States
• Advance Eye Associates — South Dartmouth, Massachusetts, United States
• Chu Vision Institute — Bloomington, Minnesota, United States
• Minnesota Eye Care — Minnetonka, Minnesota, United States
• Ophthalmology Associates — St Louis, Missouri, United States
• Vance Thompson Vision — West Fargo, North Dakota, United States
• Comprehensive Eye Care — Westerville, Ohio, United States
• Vance Thompson Vision — Sioux Falls, South Dakota, United States
• Houston Eye Associates — Houston, Texas, United States
• Virginia Eye Consultants — Norfolk, Virginia, United States

Full record on ClinicalTrials.gov

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