International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry

Running, not enrolling

Conditions studied: Spontaneous Coronary Artery Dissection

In brief

The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center in an effort to increase the pace of participant recruitment, and thereby increase statistical power of studies related to SCAD. The ultimate goal of iSCAD Registry is to facilitate the development of best practices and clinical guidelines for preventing SCAD or its recurrence. This observational study will be prospective and retrospective in its recruitment and will collect clinical information to better understand the natural history and prognosis for SCAD.

Key facts

Study ID

NCT04496687

Run by

SCAD Alliance

People needed

2000

Starts

2019-03-08

Expected to finish

2026-12-31

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants with a new diagnosis of SCAD or a history of confirmed or suspected SCAD will be prospectively recruited from either:
• Inpatient wards of the enrolling medical centers during the acute presentation of SCAD, or
• Outpatient cardiovascular clinics of enrolling medical centers.
• Participants must be:
• 18 years of age or older
• Diagnosis of SCAD or history of SCAD based on coronary angiography, either catheter-based or coronary CTA
• Suspected SCAD by coronary angiography

You may not qualify if…

• Coronary dissection in association with atherosclerosis or as a result of iatrogenic injury
• Inability to provide informed consent
• Inability to complete study-related patient questionnaires
• Inability to understand and complete patient questionnaires independently

Where it is running

• Cedars Sinai — Los Angeles, California, United States
• UCLA (University of California, Los Angeles) — Los Angeles, California, United States
• Kaiser Permanente Northern California — San Francisco, California, United States
• University of Colorado — Aurora, Colorado, United States
• Hartford Hospital — Hartford, Connecticut, United States
• University of South Florida — Tampa, Florida, United States
• Emory Healthcare System — Atlanta, Georgia, United States
• Northwestern Medicine — Chicago, Illinois, United States
• University of Kentucky — Lexington, Kentucky, United States
• Johns Hopkins — Baltimore, Maryland, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• St. Luke's Mid America — Kansas City, Missouri, United States
• Washington University — St Louis, Missouri, United States
• Dartmouth-Hitchcock — Lebanon, New Hampshire, United States
• Catholic Medical Center — Manchester, New Hampshire, United States
• Mount Sinai — New York, New York, United States
• Columbia University Medical Center — New York, New York, United States
• Atrium Health Sanger Heart and Vascular Institute — Charlotte, North Carolina, United States
• University Hospitals--Case Western — Cleveland, Ohio, United States
• Oklahoma Heart — Oklahoma City, Oklahoma, United States
• Providence — Portland, Oregon, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Allegheny General Hospital, Allegheny Health Network — Pittsburgh, Pennsylvania, United States
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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