CASE 1320: RAI Uptake and Serum Prolactin in Thyroid Cancer

Running, not enrolling

Conditions studied: Thyroid Cancer

In brief

Radioactive iodine (RAI) is a radioisotope used to ablate thyroid gland remnant after thyroidectomy in patients diagnosed with differentiated thyroid carcinoma (DTC). A whole body scan (WBS) is performed to not only evaluate for iodine uptake by the native thyroid tissue but also to observe for uptake in other areas of the body, which could be physiological or indicative of iodide-avid metastases. Research has shown a correlation between breast cancer and thyroid cancer. Patients with DTC have been found to have elevated levels of serum prolactin, which could lead to mammary gland dysfunction. In patients with DTC undergoing RAI scanning or therapy, it has been previously observed that patients prepared by thyroid hormone withdrawal have significantly higher breast uptake on whole body scan compared to those prepared by rh-TSH. Considering the impact of prolactin on breast tissue, this study aims to correlate these findings with the lab values and the method of preparation. Accordingly, the research question is as follows: does the method of WBS preparation impact prolactin levels and how does that correlate with breast uptake in patients with DTC undergoing RAI WBS?

Key facts

Study ID

NCT04495985

Run by

The Cleveland Clinic

People needed

39

Starts

2020-07-14

Expected to finish

2026-12-01

Last updated by the study team

2026-01-28

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients with diagnosis of differentiated thyroid carcinoma who have had thyroidectomy performed previously
• Patients able to understand and sign informed consent for imaging
• Patients already scheduled to undergo radioactive iodine whole body scanning (RAI WBS)

You may not qualify if…

• Males
• Patients with a history of breast cancer
• Patients with a known history of hyperprolactinemia
• Patients receiving medications known to raise serum prolactin

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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