SARS-COV-2 Infection in Kidney Transplant Recipients: a Brazilian Multicenter Study
Recruiting now
Conditions studied: SARS-CoV-2 Infection, Kidney Transplant Infection
In brief
COVID-19 is the pandemic disease caused by the SARS-CoV-2 coronavirus. It is a highly contagious viral disease, the condition of which main clinical symptoms are characterized by fever and respiratory symptoms. Evidence indicates to worse outcomes in patients with pre-existing diseases, such as diabetes, arterial hypertension, heart disease, pneumopathies, chronic kidney disease, and immunodeficiencies. Recipients of kidney transplants make prolonged use of immunosuppressive drugs to inhibit the acquired immune response, notably the activity of lymphocytes. Due to this potential to modulate the immune and inflammatory response, it is speculated that the clinical and laboratory condition of COVID-19 in these patients is atypical. Preliminary evidence suggests worse outcomes of COVID-19 in immunosuppressed patients, as carriers of cancer. However, information on kidney transplant recipients is insufficient. So far, only reports of the case are available in the literature with different clinical presentations and outcomes. The aim of this study is, therefore, to characterize the demographics, clinical and laboratory conditions, and the outcomes of COVID-19 in kidney transplant recipients in a national multicenter cohort.
Key facts
- Study ID
- NCT04494776
- Run by
- Helio Tedesco Silva Junior
- People needed
- 500
- Starts
- 2020-05-21
- Expected to finish
- 2025-04-02
- Last updated by the study team
- 2024-11-08
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Kidney transplant recipients, which may be multi-organ recipients, transplanted in any follow-up period;
- Positive diagnostic test for COVID-19 (detection of viral load, test for detection of antigens or tests for detection of antibodies);
- Outpatient or hospital management;
- Adults and children.
Where it is running
- Hospital do Rim — São Paulo, Aão Paulo, Brazil (enrolling)
Full record on ClinicalTrials.gov
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