Study to Estimate How Common it is to Have Genetic Variants Associated With NAFLD

Completed

Conditions studied: Healthy

In brief

The purpose of this study is to estimate the prevalence of genetic variants associated with liver disease in participants who are known, or are likely to have NAFLD.

Key facts

Study ID: NCT04494360
Run by: Janssen Research & Development, LLC
People needed: 830
Starts: 2020-08-07
Expected to finish: 2022-10-10
Last updated by the study team: 2025-03-30

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

No clinically significant abnormality based on medical history, physical exam, and 12-lead electrocardiogram (ECG) collected during Visit 1
Women must be of non-childbearing potential, defined as either: a.) Postmenopausal or b.) Permanently sterile
Must be willing to provide a deoxyribonucleic acid (DNA) sample for assessment of genetic variants associated with NAFLD
Must sign an informed consent form (ICF) indicating that he or she understands the purpose of, and procedures required for, the study and is willing to participate in the study

You may not qualify if…

History or presence of drug abuse within the 2 years prior to Visit 1
Excessive use of alcohol within 2 years prior to the study
Body mass index greater than (>) 40 kilogram per meter square (kg/m\^2)
Evidence of other active (acute or chronic) liver disease other than NAFLD/ Nonalcoholic steatohepatitis (NASH)
History of bariatric surgery or planning to undergo bariatric surgery within the next year
Inability to undergo magnetic resonance imaging (MRI)

Where it is running

Research Centers of America, LLC — Hollywood, Florida, United States
PRA Health Sciences — Lenexa, Kansas, United States
Endeavor Clinical Trials, LLC — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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