The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

Recruiting now

Conditions studied: Supratentorial Hemorrhage

In brief

This registry will study the use of the Aurora® Surgiscope to provide surgical access and visualization in minimally invasive removal of hematoma in the brain. Many methods of hematoma removal are available and will be based on surgeon preference. The impact of patient selection and time to surgery from last known well time will be explored.

Key facts

Study ID

NCT04494295

Run by

Integra LifeSciences Corporation

People needed

500

Starts

2020-10-23

Expected to finish

2029-10-15

Last updated by the study team

2026-02-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject Age is > 18
• Subject with a Head CT that demonstrates an acute, spontaneous, primary, supratentorial ICH of volume > 20 mL, assessed via standard of care techniques
• Subject Surgery can be initiated within 24 hours of the last known well time or, in patients with wake-up onset, within 24 hours of the time the patient awoke with symptoms.
• Subject has a NIHSS score > 5
• Subject has a baseline Modified Rankin Scale (mRS) Score ≤ 2
• Subject with a CT Angiography demonstrating no vascular malformation

You may not qualify if…

• Subject has an underlying vascular lesion defined as causative source of ICH
• Subject has a profound neurological deficit defined as fixed/dilated pupils or bilateral extensor motor posturing
• Subject has an Infratentorial or brainstem ICH
• Subject has a known life expectancy < 6 months
• Subject has an uncorrectable coagulopathy
• Subject has a mechanical heart valve
• Subject is pregnant
• Subject participates in another concurrent interventional clinical trial
• Subject who is unable to meet study follow-up requirements

Where it is running

• University of Washington - Harborview — Seattle, Washington, United States (enrolling)
• University of Miami — Miami, Florida, United States (enrolling)
• University of South Florida — Tampa, Florida, United States (enrolling)
• Rush University Medical Center — Chicago, Illinois, United States (enrolling)
• Pennsylvania State University — Hershey, Pennsylvania, United States (enrolling)
• Prisma Health - Upstate — Greenville, South Carolina, United States (enrolling)
• University of Utah — Salt Lake City, Utah, United States (enrolling)
• Providence Health — Burbank, California, United States (enrolling)
• University of Missouri — Columbia, Missouri, United States (enrolling)
• Washington University in St. Louis — St Louis, Missouri, United States (enrolling)
• JFK university — Edison, New Jersey, United States (enrolling)
• University at Buffalo — Buffalo, New York, United States (enrolling)
• Icahn School of Medicine at Mount Sinai — New York, New York, United States (enrolling)
• University of North Carolina — Chapel Hill, North Carolina, United States (enrolling)
• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
• University of Oklahoma — Oklahoma City, Oklahoma, United States (enrolling)
• MedStar Health Research Institute — Baltimore, Maryland, United States
• Corewell Health — Grand Rapids, Michigan, United States
• UT Health — Houston, Texas, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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