Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

Recruiting now · Not applicable

Conditions studied: Postoperative Cognitive Decline, Postoperative Delirium, Postoperative Cognitive Dysfunction

In brief

Postoperative delirium (POD) and postoperative cognitive decline (POCD) can be observed after cardiosurgical interventions. Taken together, these postoperative neurocognitive dysfunctions contribute to increased morbidity and mortality and higher economic costs. Preoperative risk factors of postoperative neurocognitive dysfunctions, such as decreased neuropsychometric performance or decreased cognitive daily activities, can be interpreted as reduced cognitive reserve. The aim of this study is to build up cognitive reserves to protect against the development of POD and POCD through preoperative, home-based, cognitive training.

Key facts

Study ID

NCT04493996

Run by

Heart and Brain Research Group, Germany

People needed

100

Starts

2020-08-14

Expected to finish

2026-03-01

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Elective cardiac surgery (coronary artery bypass surgery, aortic or mitral valve replacement/reconstruction, or combination surgery) with standardized extracorporeal circulation
• A sufficiently good knowledge of German is necessary as cognitive training and neuropsychological tests are language-dependent

You may not qualify if…

• History of stroke and preexisting psychiatric or neurological disorders that may impair the neuropsychological performance

Where it is running

• Department of Cardiac Surgery, Kerckhoff-Klinik GmbH — Bad Nauheim, Germany (enrolling)

Full record on ClinicalTrials.gov

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