Ankle Instability Using Foot Intensive Rehabilitation

Running, not enrolling · Not applicable

Conditions studied: Ankle Injuries, Ankle Sprains

In brief

The overall objective of this study is to examine the effects of a 6-week foot-intensive rehabilitation (FIRE) program on lateral ankle sprain (LAS) re-injury rates, CAI symptoms, sensorimotor function, and self-reported disability in CAI patients.

Key facts

Study ID

NCT04493645

Run by

Matthew Hoch

People needed

150

Starts

2021-10-28

Expected to finish

2026-12-01

Last updated by the study team

2026-03-19

Who can join

Age: 18 and older, up to 44. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18-44.
• Previous history of at least 1 ankle sprain and at least 2 episodes of "giving way" in the past 3 months.
• Participants must answer "yes" to at least 5 questions on the Ankle Instability Instrument.
• Score of 11 or higher on the Identification of Functional Ankle Instability (IdFAI).
• Confirmed clinical presentation of CAI by a PT, AT, or MD.

You may not qualify if…

• Sustained an ankle sprain in the previous four weeks or lower extremity neuromusculoskeletal injury other than to the ankle in the last 12 months.
• History of surgery to the lower extremity.
• Sustained a lower extremity fracture.
• History of neurological disease, vestibular or visual disturbance or any other pathology that would impair their sensorimotor performance.
• Current participation in a formal ankle joint rehabilitation program.
• Sustained a concussion in the last 12 months.
• Exhibit clinical examination characteristics of foot and ankle function which are consistent with conditions other than CAI (i.e. fracture, deformity).

Where it is running

• University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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