A Dose-Range Finding Clinical Trial Study in Human Immunodeficiency Virus (HIV-1) Infected Treatment-Naive Adults

Stopped early · Phase 2 · Has a placebo group

Conditions studied: HIV Infections

In brief

This is a phase 2b, randomized, multicenter, parallel group, partially blind (to GSK3640254 doses \[100, 150 and 200 milligrams {mg}\]), active controlled clinical trial. It aims to investigate the safety, efficacy and dose-response of GSK3640254 compared to dolutegravir (DTG), each given in combination with 2 Nucleoside Reverse Transcriptase Inhibitors (NRTIs) (abacavir/lamivudine \[ABC/3TC\] or emtricitabine/tenofovir alafenamide \[FTC/TAF\]).

Key facts

Study ID: NCT04493216
Run by: ViiV Healthcare
People needed: 161
Starts: 2020-11-18
Expected to finish: 2023-05-29
Last updated by the study team: 2024-06-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Participants must be 18 years of age inclusive, at the time of signing the informed consent.
Treatment-naive, defined as no anti-retrovirals (ARVs) (in combination or monotherapy) received after the diagnosis of HIV-1 infection (for example [e.g.], use of Pre-exposure prophylaxis [PreP] meets inclusion.
Documented HIV infection and Screening plasma HIV-1 RNA greater than or equal to (>=)1000 c/mL.
Screening CD4+ T-cell count >=250 cells/mm\^3.
Antiviral susceptibility to the NRTI backbone selected should be demonstrated
Body weight >=50.0 kilograms (kg) (110 pounds [lbs]) for men and >=45.0 kg (99 lbs) for women and body mass index (BMI) greater than (>)18.5 kg/meter square (m\^2).Calculations utilized sex assigned at birth
Participants who are male at birth and participants who are female at birth.
Participants who are female at birth: Contraceptive use by participant who are female at birth should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
A participant who was female at birth was eligible to participate if they were not pregnant or breastfeeding, and one of the following conditions applies:
Was a participant of non-childbearing potential (PONCBP)
Or was a POCBP and using an acceptable contraceptive method during the study intervention period (at a minimum until after the last dose of study intervention).
Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
For participants enrolled in France: a participant was eligible for inclusion in this study only if either affiliated to or a beneficiary of a social security category.

You may not qualify if…

Any evidence of an active Center for Disease Control and Prevention (CDC) Stage 3 disease, except cutaneous Kaposi's sarcoma not requiring systemic therapy.
Ongoing malignancy other than cutaneous Kaposi's sarcoma, basal cell carcinoma, or resected, non-invasive cutaneous squamous cell carcinoma, or cervical, anal or penile intraepithelial neoplasia.
Presence of primary HIV-1 infection, evidenced by acute retroviral syndrome (e.g., fever, malaise, fatigue) and/or evidence of recent (within 3 months) documented viremia without antibody production and/or evidence of recent (within 3 months) documented seroconversion.
Known history of liver cirrhosis with or without viral hepatitis co-infection.
Unstable liver disease (as defined by any of the following: presence of ascites, encephalopathy, coagulopathy, hypoalbuminemia, esophageal or gastric varices, or persistent jaundice or cirrhosis), known biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones or otherwise stable chronic liver disease per investigator assessment).
History of ongoing or clinically relevant hepatitis within the previous 6 months.
History of drug or other allergy that, in the opinion of the Investigator or Medical Monitor, contraindicates their participation.
Any history of significant underlying psychiatric disorder, in the opinion of the Investigator or ViiV Medical Monitor, including but not limited to schizophrenia, bipolar disorder with or without psychotic symptoms, other psychotic disorders, or schizotypal (personality) disorder or a clinical assessment of suicidality based on the responses on the Columbia-Suicide Severity Rating Scale (eCSSRS).
Any history of major depressive disorder with or without suicidal features, or anxiety disorders, that required medical intervention (pharmacologic or not) such as hospitalization or other inpatient treatment and/or chronic (>6 months) outpatient treatment.
Any pre-existing physical or other psychiatric condition (including alcohol or drug abuse), which, in the opinion of the Investigator or ViiV Medical Monitor (with or without psychiatric evaluation), could interfere with the participant's ability to comply with the dosing schedule and protocol evaluations or which might compromise the safety of the participant.
A pre-existing condition, in the opinion of the Investigator or ViiV Medical Monitor, that could interfere with normal gastrointestinal anatomy or motility (e.g., gastroesophageal reflux disease [GERD], gastric ulcers, gastritis, inflammatory bowel disease), hepatic and/or renal function, or with the absorption, metabolism, and/or excretion of the study drugs or render the participant unable to take oral study treatment.
Myocardial infarction in the past 3 months.
Familial or personal history of long QT syndrome or sudden cardiac death.
Medical history, current or historical, of significant cardiac arrhythmias or Electrocardiogram (ECG) findings which, in the opinion of the Investigator or ViiV Medical Monitor, will interfere with the safety of the participant.
Active Treatment for a viral infection other than HIV-1, such as Hepatitis B, with an agent that is active against HIV-1 (were known to be infected with HIV-1 after treatment for Hepatitis B was completed).
Treatment with an HIV-1 immunotherapeutic vaccine within 90 days of Screening.
Treatment with any of the following agents within 28 days of Screening: radiation therapy, cytotoxic chemotherapeutic agents, any systemic immune suppressant.
Participants receiving any protocol-prohibited medication and who are unwilling or unable to switch to an alternate medication.
Participants who are unwilling to stop any medications as required by the local lab test for Helicobacter (H.) pylori.
Participants who require concomitant medications known to be associated with a prolonged Corrected QT interval (QTc).
Exposure to an experimental drug, human blood product, monoclonal antibody, or vaccine (which does not have emergency, conditional or standard market authorization) within 28 days prior to the first dose of study treatment.
Current enrollment or past participation within the last 30 days before signing of consent in any other clinical study involving an investigational study intervention (including an investigational Coronavirus Disease (COVID) vaccine) or any other type of medical research.
Any evidence of viral resistance based on the NRTI backbone selected.
Historical evidence (prior to study screening period) of the presence of resistance- associated mutations gag A364V or A364A/V.
Creatinine Clearance <50 mL/minute.

Where it is running

GSK Investigational Site — Ft. Pierce, Florida, United States
GSK Investigational Site — Orlando, Florida, United States
GSK Investigational Site — Orlando, Florida, United States
GSK Investigational Site — Berkley, Michigan, United States
GSK Investigational Site — Jackson, Mississippi, United States
GSK Investigational Site — Omaha, Nebraska, United States
GSK Investigational Site — Cincinnati, Ohio, United States
GSK Investigational Site — Dallas, Texas, United States
GSK Investigational Site — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
GSK Investigational Site — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
GSK Investigational Site — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
GSK Investigational Site — Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
GSK Investigational Site — Ciudad de Buenos Aires, Buenos Aires, Argentina
GSK Investigational Site — Buenos Aires, Argentina
GSK Investigational Site — Buenos Aires, Argentina
GSK Investigational Site — San Juan, Argentina
GSK Investigational Site — Ottawa, Ontario, Canada
GSK Investigational Site — Montreal, Quebec, Canada
GSK Investigational Site — Montreal, Quebec, Canada
GSK Investigational Site — Montreal, Quebec, Canada
GSK Investigational Site — Marseille, France
GSK Investigational Site — Paris, France
GSK Investigational Site — Tourcoing, France
GSK Investigational Site — Munich, Bavaria, Germany
GSK Investigational Site — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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